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Traffic delays can be expected during the lane closures, which begin at 10 p.m. Saturday and run through 10 p.m. Oct. 29, according to a CTA press release.
The lane closures are part of $280 million upgrade to the South Side rail station and bus terminal. Construction began in late 2014, and the station has remained open during the project.
The south terminal is scheduled to be completed in early 2018, and the north terminal will be ready in late 2018, CTA officials said.
The 95th Street terminal was built in 1969.